2024

• Wazir S, Parviainen TAO, Pfannenstiel JJ, Duong MTH, Cluff D, Sowa ST, Galera-Prat A, Ferraris D, Maksimainen MM, Fehr AR, Heiskanen JP, Lehtiö L. Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target. J Med Chem. 2024 Apr 25;67(8):6519-6536. doi: 10.1021/acs.jmedchem.3c02451. Epub 2024 Apr 9. PMID: 38592023; PMCID: PMC11144470
• Study reports new compound halting replication of COVID by targeting ‘Mac-1’ protein in cell models
• Otter CJ, Bracci N, Parenti NA, Ye C, Asthana A, Blomqvist EK, Tan LH, Pfannenstiel JJ, Jackson N, Fehr AR, Silverman RH, Burke JM, Cohen NA, Martinez-Sobrido L, Weiss SR. SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320194121. doi: 10.1073/pnas.2320194121. Epub 2024 Apr 3. PMID: 38568967; PMCID: PMC11009620.
• Kerr CM, Pfannenstiel JJ, Alhammad YM, O’Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. PMID: 39387584; PMCID: PMC11575489.

2023

• O’Connor JJ, Ferraris D, Fehr AR. An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors. Pathogens. 2023 Oct 7;12(10):1221. doi: 10.3390/pathogens12101221. PMID: 37887737; PMCID: PMC10610136.
• O’Connor JJ, Voth L, Athmer J, George NM, Connelly CM, Fehr AR. Two Commercially Available Blood-Stabilization Reagents Serve as Potent Inactivators of Coronaviruses. Pathogens. 2023 Aug 25;12(9):1082. doi: 10.3390/pathogens12091082. PMID: 37764890; PMCID: PMC10534660.
• Alhammad YM, Parthasarathy S, Ghimire R, Kerr CM, O’Connor JJ, Pfannenstiel JJ, Chanda D, Miller CA, Baumlin N, Salathe M, Unckless RL, Zuñiga S, Enjuanes L, More S, Channappanavar R, Fehr AR. SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120. Epub 2023 Aug 22. PMID: 37607224; PMCID: PMC10468617.
• NEW GRASP OF KEY COVID-19 PROTEIN MAY LEAD TO A LIVE-ATTENUATED VACCINE EFFECTIVE AGAINST MORE VARIANTS FOR LONGER
• Kerr CM, Parthasarathy S, Schwarting N, O’Connor JJ, Pfannenstiel JJ, Giri E, More S, Orozco RC, Fehr AR. PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner. J Virol. 2023 Sep 28;97(9):e0088523. doi: 10.1128/jvi.00885-23. Epub 2023 Sep 11. PMID: 37695054; PMCID: PMC10537751.
• Ly CY, Pfannenstiel J, Pant A, Yang Z, Fehr AR, Rodzkin MS, Davido DJ. Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles. Microbiol Spectr. 2023 Feb 14;11(1):e0194322. doi: 10.1128/spectrum.01943-22. Epub 2022 Dec 20. PMID: 36537798; PMCID: PMC9927324.

2022

• Parthasarathy S, Fehr AR. PARP14: A key ADP-ribosylating protein in host-virus interactions? PLoS Pathog. 2022 Jun 9;18(6):e1010535. doi: 10.1371/journal.ppat.1010535. PMID: 35679255; PMCID: PMC9182250.
• Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain. Bioorg Med Chem. 2022 Aug 1;67:116788. doi: 10.1016/j.bmc.2022.116788. Epub 2022 May 11. PMID: 35597097; PMCID: PMC9093066.
• Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening. Antiviral Res. 2022 May 19;203:105344. doi: 10.1016/j.antiviral.2022.105344. Epub ahead of print. PMID: 35598780; PMCID: PMC9119168.
• Comar CE, Otter CJ, Pfannenstiel J, Doerger E, Renner DM, Tan LH, Perlman S, Cohen NA, Fehr AR, Weiss SR. MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2123208119. doi: 10.1073/pnas.2123208119. Epub 2022 May 20. PMID: 35594398.
• Leung AKL, Griffin DE, Bosch J, Fehr AR. The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses. Pathogens. 2022 Jan 14;11(1):94. doi: 10.3390/pathogens11010094. PMID: 35056042; PMCID: PMC8780475.

2021

• Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL. High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain. ACS Chem Biol. 2022 Jan 21;17(1):17-23. doi: 10.1021/acschembio.1c00721. Epub 2021 Dec 14. PubMed PMID: 34904435; PubMed Central PMCID: PMC8691451.
• Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M. ADP-ribosyltransferases, an update on function and nomenclature. FEBS J. 2021 Jul 29;. doi: 10.1111/febs.16142. [Epub ahead of print] PubMed PMID: 34323016.
• Voth LS, O’Connor JJ, Kerr CM, Doerger E, Schwarting N, Sperstad P, Johnson DK, Fehr AR. Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication. J Virol. 2021 Jul 12;95(15):e0076621. doi: 10.1128/JVI.00766-21. Epub 2021 Jul 12. PubMed PMID: 34011547; PubMed Central PMCID: PMC8274620. 
• Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase. J Virol. 2021 Jan 13;95(3). doi: 10.1128/JVI.01969-20. Print 2021 Jan 13. PubMed PMID: 33158944; PubMed Central PMCID: PMC7925111.

2020

• Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR^#, Brenner C^#. Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. J Biol Chem. 2020 Dec 25;295(52):17986-17996. doi: 10.1074/jbc.RA120.015138. Epub 2020 Oct 13. PubMed PMID: 33051211; PubMed Central PMCID: PMC7834058.
• Ghosh S, Dellibovi-Ragheb TA, Kerviel A, Pak E, Qiu Q, Fisher M, Takvorian PM, Bleck C, Hsu VW, Fehr AR, Perlman S, Achar SR, Straus MR, Whittaker GR, de Haan CAM, Kehrl J, Altan-Bonnet G, Altan-Bonnet N. β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway. Cell. 2020 Dec 10;183(6):1520-1535.e14. doi: 10.1016/j.cell.2020.10.039. Epub 2020 Oct 27. PubMed PMID: 33157038; PubMed Central PMCID: PMC7590812.
• Alhammad YMO, Fehr AR. The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation. Viruses. 2020 Mar 31;12(4). doi: 10.3390/v12040384. Review. PubMed PMID: 32244383; PubMed Central PMCID: PMC7232374.
• Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M. The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions. Genes Dev. 2020 Mar 1;34(5-6):341-359. doi: 10.1101/gad.334425.119. Epub 2020 Feb 6. Review. PubMed PMID: 32029454; PubMed Central PMCID: PMC7050484.
• Grunewald ME, Shaban MG, Mackin SR, Fehr AR, Perlman S. Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression. J Virol. 2020 Jan 17;94(3). doi: 10.1128/JVI.01743-19. Print 2020 Jan 17. PubMed PMID: 31694960; PubMed Central PMCID: PMC7000979.
• Fehr AR. Bacterial Artificial Chromosome-Based Lambda Red Recombination with the I-SceI Homing Endonuclease for Genetic Alteration of MERS-CoV. Methods Mol Biol. 2020;2099:53-68. doi: 10.1007/978-1-0716-0211-9_5. PubMed PMID: 31883087; PubMed Central PMCID: PMC7121842.

2019

• Channappanavar R, Fehr AR, Zheng J, Wohlford-Lenane C, Abrahante JE, Mack M, Sompallae R, McCray PB Jr, Meyerholz DK, Perlman S. IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes. J Clin Invest. 2019 Jul 29;129(9):3625-3639. doi: 10.1172/JCI126363. eCollection 2019 Jul 29. PubMed PMID: 31355779; PubMed Central PMCID: PMC6715373.
• Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S^#, Fehr AR^#. The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression. PLoS Pathog. 2019 May;15(5):e1007756. doi: 10.1371/journal.ppat.1007756. eCollection 2019 May. PubMed PMID: 31095648; PubMed Central PMCID: PMC6521996.

2018

• Fehr AR, Jankevicius G, Ahel I, Perlman S. Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis. Trends Microbiol. 2018 Jul;26(7):598-610. doi: 10.1016/j.tim.2017.11.011. Review. PubMed PMID: 29268982; PubMed Central PMCID: PMC6003825.
• Athmer J*, Fehr AR*, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M Jr, Denison MR, Perlman S. Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses. mBio. 2018 May 1;9(3). doi: 10.1128/mBio.00272-18. PubMed PMID: 29717007; PubMed Central PMCID: PMC5930304.
• Galasiti Kankanamalage AC, Kim Y, Damalanka VC, Rathnayake AD, Fehr AR, Mehzabeen N, Battaile KP, Lovell S, Lushington GH, Perlman S, Chang KO, Groutas WC. Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. Eur J Med Chem. 2018 Apr 25;150:334-346. doi: 10.1016/j.ejmech.2018.03.004. Epub 2018 Mar 6. PubMed PMID: 29544147; PubMed Central PMCID: PMC5891363.
• Grunewald ME, Fehr AR, Athmer J, Perlman S. The coronavirus nucleocapsid protein is ADP-ribosylated. Virology. 2018 Apr;517:62-68. doi: 10.1016/j.virol.2017.11.020. Epub 2017 Dec 1. PubMed PMID: 29199039; PubMed Central PMCID: PMC5871557.
• Canton J*, Fehr AR*, Fernandez-Delgado R, Gutierrez-Alvarez FJ, Sanchez-Aparicio MT, García-Sastre A, Perlman S, Enjuanes L, Sola I. MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection. PLoS Pathog. 2018 Jan;14(1):e1006838. doi: 10.1371/journal.ppat.1006838. eCollection 2018 Jan. PubMed PMID: 29370303; PubMed Central PMCID: PMC5800688.

2017

• Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S. Virus-induced inflammasome activation is suppressed by prostaglandin D₂/DP1 signaling. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5444-E5453. doi: 10.1073/pnas.1704099114. Epub 2017 Jun 19. PubMed PMID: 28630327; PubMed Central PMCID: PMC5502630.
• Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S. In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. mBio. 2017 Jan 31;8(1). doi: 10.1128/mBio.02320-16. PubMed PMID: 28143984; PubMed Central PMCID: PMC5285509.
• Fehr AR, Channappanavar R, Perlman S. Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus. Annu Rev Med. 2017 Jan 14;68:387-399. doi: 10.1146/annurev-med-051215-031152. Epub 2016 Aug 26. Review. PubMed PMID: 27576010; PubMed Central PMCID: PMC5353356.

2016

• Fehr AR, Channappanavar R, Jankevicius G, Fett C, Zhao J, Athmer J, Meyerholz DK, Ahel I, Perlman S. The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. mBio. 2016 Dec 13;7(6). doi: 10.1128/mBio.01721-16. PubMed PMID: 27965448; PubMed Central PMCID: PMC5156301.
• Park JE, Li K, Barlan A, Fehr AR, Perlman S, McCray PB Jr, Gallagher T. Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12262-12267. doi: 10.1073/pnas.1608147113. Epub 2016 Oct 10. PubMed PMID: 27791014; PubMed Central PMCID: PMC5086990.
• Channappanavar R, Fehr AR, Vijay R, Mack M, Zhao J, Meyerholz DK, Perlman S. Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell Host Microbe. 2016 Feb 10;19(2):181-93. doi: 10.1016/j.chom.2016.01.007. PubMed PMID: 26867177; PubMed Central PMCID: PMC4752723.

2015

• Fehr AR, Athmer J, Channappanavar R, Phillips JM, Meyerholz DK, Perlman S. The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis. J Virol. 2015 Feb;89(3):1523-36. doi: 10.1128/JVI.02596-14. Epub 2014 Nov 26. PubMed PMID: 25428866; PubMed Central PMCID: PMC4300739.
• Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015;1282:1-23. doi: 10.1007/978-1-4939-2438-7_1. Review. PubMed PMID: 25720466; PubMed Central PMCID: PMC4369385.

Complete List of Published Work in MyBibliography:  

https://www.ncbi.nlm.nih.gov/sites/myncbi/anthony.fehr.1/bibliography/50266689/public/?sortby=pubDate&sdirection=ascending